Preprints

1. Yang H, Chen G, Lima L, Fang H, Jimenez-Barron LT, Li M, Lyon GJ, He M#, Wang K#. (2015) PennCNV-Hadoop: Accurate Detection of Copy Number Variation from Whole Genome Sequencing Data. Manuscript submitted.

 

Publications

Publications (as a Principal Investigator)

66. Fang H, Wu Y, Jiménez-Barrón LT, O’Rawe JA, Highnam G, Mittelman G, Lyon GJ. (2016). Whole genome sequencing of one complex pedigree illustrates challenges with genomic medicine. BMC Med Genomics. 2017 Feb 23;10(1):10. doi: 10.1186/s12920-017-0246-5. PMID: 28228131.  (View PDF)

65. Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ. (2016). KBG syndrome involving a single base insertion in ANKRD11, Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001131. PMID: 27900361. (View PDF)

64. Malcolmson J, Kleyner R, Tegay D, Adams W, Ward K, Coppinger J, Nelson L, Meisler MH, Wang K, Robison R, Lyon GJ. (2016) SCN8A Mutation in a Child Presenting with Seizures and Developmental Delays, Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001073. PMID: 27900360. (View PDF) (View Pubmed)

63. Fang H, Bergmann EA, Arora K, Vacic V, Zody MC, Iossifov I, O’Rawe JA, Wu Y, Jimenez Barron LT, Rosenbaum J, Ronemus M, Lee YH, Wang Z, Dikoglu E, Jobanputra V, Lyon GJ, Wigler M, Schatz MC, Narzisi G. Indel variant analysis of short-read sequencing data with Scalpel. Nat Protoc. 2016 Dec;11(12):2529-2548. doi: 10.1038/nprot.2016.150. PMID:27854363 (View Pubmed)

62. Köhler S, Vasilevsky NA, Engelstad M, Foster E, McMurry J, Aymé S, Baynam G, Bello SM, Boerkoel CF, Boycott KM, Brudno M, Buske OJ, Chinnery PF, Cipriani V, Connell LE, Dawkins HJ, DeMare LE, Devereau AD, de Vries BB, Firth HV, Freson K, Greene D, Hamosh A, Helbig I, Hum C, Jähn JA, James R, Krause R, Laulederkind SJ, Lochmüller H, Lyon GJ, Ogishima S, Olry A, Ouwehand WH, Pontikos N, Rath A, Schaefer F, Scott RH, Segal M, Sergouniotis PI, Sever R, Smith CL, Straub V, Thompson R, Turner C, Turro E, Veltman MW, Vulliamy T, Yu J, von Ziegenweidt J, Zankl A, Züchner S, Zemojtel T, Jacobsen JO, Groza T, Smedley D, Mungall CJ, Haendel M, Robinson PN. The Human Pnenotype Ontology in 2017.  Nucleic Acids Res. 2017 Jan 4;45(D1):D865-D876. doi: 10.1093/nar/gkw1039. PMID:27899602 (View Pubmed)

61. Darrow SM, Hirschtritt ME, Davis LK, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman CL, Cath DC, Greenberg E, Lyon GJ, Yu D, McGrath LM, McMahon WM, Lee PC, Delucchi KL, Scharf JM, Mathews CA; Tourette Syndrome Association International Consortium for Genetics. Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome. Am J Psychiatry. 2016 Nov 4:appiajp201616020240. [Epub ahead of print] PMID:27809572 (View Pubmed)

60. Dörfel MJ, Fang H, Crain J, Klingener M, Weiser J, Lyon GJ. Proteomic and genomic characterization of a yeast model for Ogden syndrome Yeast. 2017 Jan;34(1):19-37. doi: 10.1002/yea.3211. PMID:27668839 doi: http://dx.doi.org/10.1101/045047. (View PDF) (View Pubmed)

59. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, King RA, Sandor P, McMahon WM, Lyon GJ, Cath DC, Kurlan R, Robertson MM, Osiecki L, Scharf JM, Mathews CA; for the Tourette Syndrome Association International Consortium for Genetics. (2016). Social disinhibition is a heritable subphenotype of tics in Tourette syndrome. Neurology. 2016 Aug 2;87(5):497-504. doi: 10.1212/WNL.0000000000002910. PMID: 27371487 (View PubMed)

58. Shi L, Guo Y, Dong C, Huddleston J, Yang H, Han X, Fu A, Li Q, Li N, Gong S, Lintner KE, Ding Q, Wang Z, Hu J, Wang D, Wang F, Wang L, Lyon GJ, Guan Y, Shen Y, Evgrafov OV, Knowles JA, Thibaud-Nissen F, Schneider V, Yu CY, Zhou L, Eichler EE, So KF, Wang K. Long-read sequencing and de novo assembly of a Chinese genome. Nat Commun. 2016 Jun 30;7:12065. doi: 10.1038/ncomms12065. PMID: 27356984. (View PDF) (View PubMed)

57. Desai A, Connolly JJ, March M, Hou C, Chiavacci R, Kim C, Lyon GJ, Hadley D, Hakonarson H. Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant. Bmc Musculoskeletal Disorders. 17: 80. PMID 26879370 DOI:10.1186/s12891-016-0936-8. (View PDF)

56.  Lyon GJ, Bird LM, Rope A. (2016).  X-linked Malformation and Infantile Lethality Syndrome (provisionally named Ogden Syndrome). In: Inborn errors of development. Oxford University Press, Oxford; New York. ISBN 9780195306910. (View PDF)

55. O’Rawe JA, Wu Y, Doerfel M, Rope A, Billie Au PY, Parboosingh JS, Moon S, Kousi M, Kosma K, Smith CS, Tzetis M, Schuette JL,  Hufnagel RB, Prada CE, Martinez F, Orellana C,  Crain J, Caro-Llopis A, Oltra S, Monfort S, Jiménez-Barrón LT, Swensen J, Ellingwood S, Smith R, Fang H, Ospina S, Stegmann S, Den Hollander N, Mittelman D, Highnam G, Robison R, Yang E, Faivre L, Roubertie A, Rivière JB, Monaghan KG, Wang K, Davis EE, Katsanis N, Kalscheuer VM, Wang E, Metcalfe K, Kleefstra T, Innes AM, Kitsiou-Tzeli S, Rosello M, Keegan CE, Lyon GJ#. (2015). TAF1 Variants are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations.  Am J Hum Genet. 2015 Dec 3;97(6):922-32. doi: 10.1016/j.ajhg.2015.11.005. PMID:26637982 (View PDF)

54. Jiménez-Barrón LT, O’Rawe JA, Wu Y, Yoon M, Fang H, Iossifov I, Lyon GJ. (2015). Genome-wide variant analysis of simplex autism families with an integrative clinical-bioinformatics pipeline.  Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000422. doi: 10.1101/mcs.a000422. PMID:27148569 (View PDF)

53. Guo Y, Ding X, Shen Y, Lyon GJ, Wang K. (2015). SeqMule: automated pipeline for analysis of human exome/genome sequencing data.  Sci Rep. 2015 Sep 18;5:14283. doi: 10.1038/srep14283. PMID: 26381817 (View PDF) (View PubMed)

52. Lyon GJ# and O’Rawe JA. (2015). Human genetics and clinical aspects of neurodevelopmental disorders. In: The Genetics of Neurodevelopmental Disorders. Wiley. (View PDF)

51. Doerfel M and Lyon GJ#. (2015). The biological functions of Naa10 – from amino-terminal acetylation to human disease. Gene. 2015 Aug 10;567(2):103-31. doi: 10.1016/j.gene.2015.04.085. Review. PMID:25987439. (View Preprint PDF) (Revised Version 2015) (View Final PDF) (View PubMed)

50. Lyon GJ#. (2015) Cut the Hype. Accuracy and Standards Come First. Interview, Frontline Genomics Magazine.  (View PDF)

49. O’Rawe JA#, Ferson S#, Lyon GJ#. (2015). Accounting for uncertainty in DNA sequencing data. Trends Genet. 2015 Feb;31(2):61-6. doi: 10.1016/j.tig.2014.12.002. Review. PMID:25579994. http://www.sciencedirect.com/science/article/pii/S0168952514002091. (View PDF) (View PubMed)

48. He M#, Person TN, Hebbring SJ, Heinzen E, Ye Z, Schrodi SJ, McPherson EW, Lin SM, Peissig PL, Brilliant MH, O’Rawe J, Robison RJ, Lyon GJ, Wang K#. (2014). SeqHBase: a big data toolset for family based sequencing data analysis.  J Med Genet. 2015 Apr;52(4):282-8. doi: 10.1136/jmedgenet-2014-102907. PMID: 25587064 http://jmg.bmj.com/content/early/2015/01/13/jmedgenet-2014-102907.long. (View PDF) (View PubMed)

47. Barash CI and Lyon GJ#. (2014). Open access and data sharing: Easier said than done. Applied & Translational Genomics. (0). doi: http://dx.doi.org/10.1016/j.atg.2014.09.008. (View In Press Publication)

46. Shi L, Li B, Huang Y, Liu T, Lyon GJ, Xu A#, Wang K#. (2014). “Genotype-first” approaches on a curious case of idiopathic progressive cognitive decline. BMC Med Genomics. 2014 Dec 3;7:66. doi: 10.1186/s12920-014-0066-9. PMID:25466957 (View PDF) (View PubMed)

45. Fang H, Wu Y, Narzisi G, O’Rawe JA, Jimenez Barron LT, Rosenbaum J, Ronemus M, Iossifov I, Schatz MC#, Lyon GJ#. (2014). Reducing INDEL calling errors in whole-genome and exome sequencing. Genome Med. 2014 Oct 28;6(10):89. doi: 10.1186/s13073-014-0089-z. PMID:25426171 (View PDF) (View PubMed)

44. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, King RA, Sandor P, McMahon WM, Lyon GJ, Cath DC, Kurlan R, Robertson MM, Osiecki L, Scharf JM, Mathews CA#. (2015). Lifetime Prevalence, Age of Risk, and Etiology of Comorbid Psychiatric Disorders in Tourette Syndrome. Tourette Syndrome Association International Consortium for Genetics. JAMA Psychiatry. 2015 Apr;72(4):325-33. doi: 10.1001/jamapsychiatry.2014.2650. PMID:25671412 [Epub ahead of print] (View PDF)

43. McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O’Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W,…57 other authors. (2014). Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study. Journal of American Academy of Child & Adolescent Psychiatry, 53(8):910-9. PMCID: PMC4218748. PMID: 25062598 (View PDF) (View PubMed)

42. Myklebust LM, Van Damme P#, Støve SI, Kalvik TV, Abboud A, Grauffel C, Dörfel M, Jonckheere V, Kaasa H, Liszczak G, Marmorstein R, Reuter N, Lyon GJ#, Gevaert K, Arnesen T#. (2014). Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet. 2015 Apr 1;24(7):1956-76. doi: 10.1093/hmg/ddu611. PMID: 25489052 http://hmg.oxfordjournals.org/content/early/2015/01/08/hmg.ddu611.full. (View PDF) (View PubMed)

41. Narzisi G#, O’Rawe JA, Iossifov I, Fang H, Lee YH, Wang Z, Wu Y, Lyon GJ, Wigler MH, Schatz MC. (2014). Accurate de novo and transmitted indel detection in exome-capture data using microassembly.  Nat Methods. 2014 Oct;11(10):1033-6. doi: 10.1038/nmeth.3069. PMID:25128977 (View PDF) (View Supplementary Info) (View PubMed)

40. Brownstein C, Beggs A, Margulies D#, Kohane I#, and 195 other co-authors. (2014). An international  effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology, 15(3): R53. PMCID: PMC4073084. PMID: 24667040 (View PDF) (View PubMed)

39. Wang K#, Kim C, Bradfield J, Guo Y, Toskala E, Otieno FG, Hou C, Thomas K, Cardinale C, Lyon GJ, Golhar R, Hakonarson H#. (2013). Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement. Genome Medicine, 5(7):67. PMCID: PMC3971341. PMID: 23889995 (View PDF) (View PubMed)

38. O’Rawe J, Fang H, Rynearson S, Robison RJ, Kiruluta ES, Higgins G, Eilbeck K, Reese MG, Lyon GJ#. (2013). Integrating whole genome sequencing and precision medicine in the study and clinical treatment of a severely mentally ill person. PeerJ, 1:e177. PMCID: PMC3792182. PMID: 24109560 (View PDF) (View Supplementary Video) (View Supplemental Info) (View Review History) (View PubMed)

 37. Shi L, Zhang X, Golhar R, Otieno FG, He M, Hou C, Kim C, Keating B, Lyon GJ, Wang K#, Hakonarson H#. (2013). Whole-genome sequencing in an autism multiplex family. Molecular Autism, 4(1):8. PMCID: PMC3642023. PMID: 23597238 (View PDF) (View PubMed)

36. O’Rawe J, Jiang T, Sun G, Wu Y, Wang W,  Hu J,  Bodily P,  Tian L, Hakonarson H, Johnson WE, Wei Z, Wang K#, Lyon GJ#. (2013). Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing. Genome Medicine, 5(3):28. PMCID: PMC3706896. PMID: 23537139 #Paper viewed >28,000 times and #2 in all-time views at this journal. (View PDF) (View PubMed)

35. Lyon GJ# and Segal JP#. (2013). Practical, ethical and regulatory considerations for the evolving medical and research genomics landscape. Applied & Translational Genomics, published online. 2, 34–40. Special Issue on Pharmocogenomics and Personalized Medicine. PMID: 27942444 http://www.sciencedirect.com/science/article/pii/S2212066113000021. (View PDF) (View Pubmed)

34. Lyon GJ# and Wang K#. (2012). Identifying disease mutations in genomic medicine settings: current challenges and how to accelerate progress. Genome Medicine, 4(7):58. PMCID: PMC3580414. PMID: 22830651 (View PDF) (View PubMed)

33. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, 48 other authors, Lyon GJ, …18 other authors; for the North American Brain Expression Consortium, Hardy J; for the UK Human Brain Expression Database, 14 other authors, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL#. (2012). Genome-wide association study of  Tourette Syndrome. Molecular Psychiatry, 18(6):721-8. PMCID: PMC3605224. (View PDF) (View PubMed)

32. Lyon GJ#. (2012). Personalized medicine: Bring clinical standards to human-genetics research. Nature, 482(7385):300-1. PMID: 22337032. http://www.nature.com/nature/journal/v482/n7385/full/482300a.html. (View PDF) *Covered in Nature: Secrets of the human genome disclosed (http://www.nature.com/news/2011/111004/full/478017a.html).

31. Lyon GJ#. (2012). Editorial, There is nothing “Incidental” about Unrelated Findings. Personalized Medicine, 9(2):163-166. (View PDF) (View PubMed)

30. Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI, Jr., Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, Maclean A, Blackwood D, Liu          CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W#. (2012). Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.  Molecular Psychiatry,   17(8): 818-826. PMCID: PMC3204161. PMID: 21769101  (View PDF) (View PubMed)

29. Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, Hadley D, Sleiman PMA, Zhang H, Kim CE, Robison R, Lyon GJ, Flory JH, Bradfield JP, Imielinski M, Hou C, Frackelton EC, Chiavacci RM, Sakurai T, Rabin C, Middleton FA, Thomas KA, Garris M, Mentch F, Freitag CM, Steinhausen HC, Todorov AA, Reif A, Rothenberger A, Franke B, Mick EO, Roeyers H, Buitelaar J, Lesch KP, Banaschewski T, Ebstein RP, Mulas F, Oades RD, Sergeant J, Sonuga-Barke E, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Meyer J, Pálmason H, Seitz C, Loo SK, Smalley SL, Biederman J, Kent L, Asherson P, Anney    RJL, Gaynor JW, Shaw P, Devoto M, White PS, Grant SFA, Buxbaum JD, Rapoport JL, Williams NM,        Nelson SF, Faraone SV, Hakonarson H#. (2011). Genome Wide Copy Number Variation Study Associates Metabotropic Glutamate Receptor Genes with Attention Deficit Hyperactivity Disorder. Nature Genetics. 44(1):78-84. PMID: 22138692. http://www.nature.com/ng/journal/v44/n1/full/ng.1013.html. (View PDF) (View PubMed)

28. Lyon GJ#. (2011). Interview, Personal account of the discovery of a new disease using next-generation sequencing. Pharmacogenomics. 12(11): 1519–1523. PMID: 22044413. http://www.ncbi.nlm.nih.gov/pubmed  /?term=Interview%2C +Personal+account+of+the+discovery+of+a+newdisease+using+next-generation+sequencing. (View PDF) (View PubMed)

27. Wei Z, Wang W, Hu P, Lyon GJ, Hakonarson H#. (2011). SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data. Nucleic Acids Research, 39(19): e.132. PMCID: PMC3201884. PMID: 21813454 (View PDF) (View PubMed)

26. Rope AF, Wang K, Evjenth R, Xing J, Johnston JJ, Swensen JJ, Johnson WE, Moore B, Huff CD, Bird LM, Carey JC, Opitz JM, Stevens CA, Jiang T, Schank C, Fain HD, Robison R, Dalley B, Chin S, South ST, Pysher TJ, Jorde LB, Hakonarson H, Lillehaug JR, Biesecker LG, Yandell M, Arnesen T, Lyon GJ#. (2011). Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal  Acetyltransferase Deficiency.  Am J Hum Genet. 2011 Jul 15;89(1):28-43. doi: 10.1016/j.ajhg.2011.05.017. Erratum in: Am J Hum Genet. 2011 Aug 12;89(2):345. PMID: 21700266 (View PDF) (View PubMed) *Covered in Nature: Software pinpoints cause of mystery genetic disorder (http://www.nature.com/news/2011/110623/full/news.2011.382.html).

25. Lyon GJ#, Jiang T, Van Wijk R, Wang W, Bodily P, Xing J, Tian L,  Robison RJ, Clement M, Yang L, Zhang P, Liu Y, Moore B,  Glessner J, Elia J, Reimherr F, van Solinge W, Yandell M, Hakonarson H, Wang J, Johnson WE, Wei Z, Wang K#. (2011). Exome Sequencing and Unrelated Findings in the context of Complex Disease Research: Ethical and Clinical Implications. Discovery Medicine, 12(62):41-    55. PMCID: PMC3544941. (View PDF) (View PubMed)

24. Robison RJ, Reimherr FW, Marchant BK, Kondo D, Lyon GJ, Olsen J, Christopherson D, Pommerville C, Tuya S, Johnson A, Coon H#. (2010). The Use of Emotional Dysregulation as an Endophenotype for Genetic Studies in Adults with Attention-Deficit Hyperactivity Disorder. Journal of ADHD and Related Disorders, 1(4):29-38. (View PDF)

Publications (from Postdoctoral Clinical Residencies)

23. Lyon GJ, Coffey BJ#, Castellanos XF, Woods D, Conelea C, Samar S, Bauer C, Brandt BC, Kemp JK, Lipinski CM, Trujillo MR, Lawrence ZE. (2010). Improving Tic Suppression: Comparing the Effects of Dexmethylphenidate to No Medication in Children and Adolescents with ADHD and Chronic Tic Disorders. Journal of Child Adolescent Psychopharmacology, 20(4):283-9. PMCID: PMC2958463. (View PDF) (View PubMed)

22. Lyon GJ, Samar S, Jummani R, Hirsch S, Spirgel A, Goldman R, Coffey BJ#. (2010). Aripiprazole in children and adolescents with Tourette’s Disorder: An open label safety and tolerability study. Journal of Child Adolescent Psychopharmacology, 19(6):623-33. PMCID: PMC2861961. (View PDF) (View PubMed)

21. Lyon GJ, Shprecher D, Coffey BJ# and Kurlan R#. (2010). Tourette’s Disorder. Current Treatment Options in Neurology, 12(4): 274-286. PMID: 20842587. http://www.ncbi.nlm.nih.gov/pubmed/20842587. (View PDF) (View PubMed)

20. Lyon GJ, Coffey BJ#. (2009). Complex tics and complex management in a case of severe Tourette’s disorder in an adolescent. Journal of Child Adolescent Psychopharmacology. 19(4):469-474. PMID: 19702501. http://online.liebertpub.com/doi/abs/10.1089/cap.2009.19402. (View PDF) (View PubMed)

19. Lyon GJ, Abi-Dargham A, Moore H, Lieberman JA, Javitch JA, Sulzer D#. (2009). Presynaptic regulation of dopamine transmission in schizophrenia. Schizophrenia Bulletin. 37(1):108-17. PMCID: PMC3004182. (View PDF) (View PubMed)

18. Lyon GJ, Coffey BJ#, Silva R. (2008). Post-traumatic stress disorder (PTSD) and Reactive Attachment Disorder:  Outcome in an Adolescent. Journal of Child Adolescent Psychopharmacology, 18(6):641-646. (View PDF) (View PubMed)

17. Lyon GJ and Coffey BJ#. (2008). Book Review of: Attention-Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment, 3rd Edition. Journal of Clinical Psychiatry, 69(6):1023. (View PDF)

16. Lyon GJ and Coffey BJ#. (2008). Book Review of: Treating Tourette Syndrome and Tic Disorders: A Guide for Practitioners. Douglas W. Woods, John .C. Piacentini, and John T. Walkup, 1st Edition. Journal of Child Adolescent Psychopharmacology, 18(4):411-412. (View PDF)

15. Lyon GJ#.(2008). Varenicline-induced paranoia and irritability in a patient with major depressive disorder, borderline personality disorder (stable), and methamphetamine abuse (in remission). Journal of Clinical Psychopharmacology, 28(6):720-721. PMID: 19011454. (View PDF) (View PubMed)

14. Lyon GJ# and Koplewicz HS#. (2007). Schizophrenia in childhood: Why we need much more research into early-onset psychosis. The Scientist, 21(12): 22-25, Schizophrenia Supplement. (View PDF)

Publications (from B.A., M.Phil., and Ph.D. Research)

13. Wright JS, Lyon GJ, George EA, Muir TW#, Novick RP#. (2004). Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proceedings of the National Academy of Science, 101(46):16168-16173. PMCID: PMC528941. (View PDF) (View PubMed)

12. Lyon GJ and Novick RP#. (2004). Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides, 25(9):1389-1403. PMID: 15374643. (View PDF) (View PubMed)

11. Lyon GJ and Muir TW#. (2003). Chemical Signaling among Bacteria and its inhibition. Chemistry and Biology, 10(11): 1007-1025. PMID: 14652068. (View PDF) (View PubMed)

10. Kalkum M, Lyon GJ, and Chait BT#. (2003). Detection of Secreted Peptides using Hypothesis driven Multistage Mass Spectrometry. Proceedings of the National Academy of Science, 100(5): 2795-2800.         PMCID: PMC151420. (View PDF) (View PubMed)

9.   Miller JS, Dudkin VY, Lyon GJ, Muir TW, and Danishefsky SJ#. (2003). Toward Homogeneous, Synthetic N-Linked Glycoproteins. Angewandte Chemie International Edition, 42(4): 431-434. (View PDF) (View PubMed)

8. Lyon GJ, Wright JS, Muir TW#, and Novick R#. (2002). Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry, 41(31): 10095-10104. PMID: 12146974. (View PDF) (View PubMed)

7. Lyon GJ, Wright JS, Christopoulous A, Novick R#, and Muir TW#. (2002). Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. Journal of Biological Chemistry, 277(8):6247-6253. PMID: 11733525. (View PDF) (View PubMed)

6. Lyon GJ, Mayville P, Muir TW#, and Novick RP#. (2000). Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proceedings of the National Academy of Sciences, 97(24): 13330-13335. PMCID: PMC27224. (View PDF) (View PubMed)

5.   Jarraud S, Lyon GJ, Figueiredo AM, Lina G, Vandenesch F, Etienne J, Muir TW, and Novick RP#. (2000). Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. Journal of Bacteriology, 182(22): 6517-6522. PMCID: PMC94802. (View PDF) (View PubMed)

4.   Fuortes M#, Melchior M, Han H, Lyon GJ, and Nathan, C. (1999). Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. Journal of Clinical Investigation, 104(3): 327-335. PMCID: PMC408415. (View PDF) (View PubMed)

3.   Hernandez A, Lyon GJ, Schneider MJ, and St Germain, DL#. (1999). Isolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase. Endocrinology, 140(1): 124-130. PMID: 9886816. (View PDF) (View PubMed)

2.   Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, and Colledge WH#. (1998). Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. Embo Journal, 17(7):1860-1870. PMCID: PMC1170533. (View PDF) (View PubMed)

1.   Hernandez A, Park JP, Lyon GJ, Mohandas TK, and St Germain DL#. (1998). Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Genomics 53(1): 119-121. PMID: 9787088. (View PDF) (View PubMed)